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Acronym of "Shut The Fuck Up", also known as something you should say to anyone that has an opinion or in case you are tired of people arguing over bullshit. It's also something you should do if you just don't like something. Science approves that shutting the fuck up for who has an opinion is the best thing you can ever do!
Someone disagrees with you on Twitter? STFU! -- AncientReality
stfu by ThatLessHandsomeGuy February 9, 2017
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Can you please “stfu”
Stfu by Destiny_dgaf01 January 21, 2018
What you say to your mum if she's being a cheeky cunt.
"Oi, bitch! Stop bein' a speccy coon and stfu!"
Boy 1: Hey man what up how are you doing you wanna go play games......

Boy 2: Oh my god man STFU you are so annoying
Stfu by Gupyfordeath February 14, 2019
Your a retard stfu
Stfu by FKNBITCHASS July 30, 2019