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Basically means shit. Originated from the television show FarScape.
"You dren hole"
"What is that piece of dren?"
"Dren"
Related Words
A user name commonly used on the internet. Mostly thought of as "nerd" spelled backwards.
The Farscape equivalent of the word 'shit'.

In response to people's lame "nerd backwards" definitions - If someone got called a dren, real nerds would take that as being called a shit. And real nerds are frelling awesome.
*Have a bite of a disgusting biscuit*
"Ugh, you really expect me to eat this dren?"
Dren by NinjaRobot August 8, 2012
You're a KROD!
Well, you're a DREN!
dren by YIPPEE HAHA! October 13, 2003
a rare species that is half man half turtlue, the creature can live up to 150 years old but its very unlikley as it feeds only on custard doughnuts and rotting flesh. this particular word is now being used as a insult.
Dren by cmcc003 January 24, 2011
nerd backwards. Most peope don't know what it means, so if you call them a "dren" they will not be offended. So you can make an inside joke with your friends if you dislike the nerd.
You: That kid is such a dren
The dren: Wow you're kool making up words
Your friends and you:(laughing) at the dren
dren by Mike Graves May 17, 2006