Salty Pants Share definition Flag To be uncomfortable in your trousers.....like having "salt in your pants". What's up with homeboy? He's acting a fool, like he's got "SALTY PANTS!?" Salty Pants by J. Wiles June 25, 2006 0 0 Get merch Get the Salty Pants mug. Buy Now — $32.95 See more merch