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your granny a tranny 

Almost the worst and most devastating insult one could deliver to another. Only thing that can beat it would be 'Ur grandpap a trap'
Ben: ur mom gay...
Alex: your granny a tranny...
Ben: *wiped from existence*

your granny a tranny 

one the most lethal jokes of all time. Only time usable as comeback when being flamed in public.
random guy "Your fit is garbage my guy are those New Balance?" You "Your granny a tranny."