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When somebody lets out about 22 liters of silent gas from a very filthy, unwashed, shit encrusted asshole and it smells Zackley like SHIT.
As Scooby Doo and the gang had another mystery on their hands, they were cruising in The Mystery machine and all of a sudden Fred smells something coming from the way, way back and he says... "I don't know if it's you Shaggy, or you Scooby, but one of you has a serious case of The Zackleys" Scooby: "Uhhh?" Shaggy: "Zoinks , like, I don't know what The Zackleys are Fred." Fred: "Since Velma is a girl and Daphne is a girl and girls don't fart, and I can see Scooby's asshole, by the process of elimination, the person with The Case of the Zackleys is YOU SHAGGY. You farted and it smells Zackley like shit. Besides, you are such a filthy looking, grimy mother fucker, I'm sure you have a crusty asshole and you must have a load of brown foam in your under britches because I can see it running out your pant leg. Now I know why you always wear brown pants. MYSTERY SOLVED. You Shaggy, have a case of the Zackleys, you filthy mother fucker."
Zackleys by Doyle_Hargraves February 25, 2020
Related Words
bowl full of assholesmorning breath--having bad breath that smells exactly like one's ass.
"man what did you eat? You got the zackleys--your breath smells zackley like your asshole.
Zackleys by igormanicus April 29, 2006

The Zacklees 

After a long night of drinking, when you wake up with that taste in your mouth, which tastes "zacklee like your asshole."
Don: So Paul, you have a good time getting trashed last night?
Paul: Ya Don, but do I ever have the zacklees right now!
Don: No worries buddy, me too.
The Zacklees by Mizou October 14, 2005

zackley's disease 

Pungent feet stench, that can drive away normal humans on a range of 15 meters, and allure carcass-eating beasts like vultures and hyeenas.

Firstly acknowledged in Pantera's video "Three - Watch it Go!", by Dimebag Darrel, Phd.
John Doe: "Whatta hell is that stench?"
Jane Doe: "It's your mother. She has zackley's disease. Die."

ZACKLEES 

Leroy: "Yo Fozzy, you got a bad case of the ZACKLEES!"

Fozzy: "What'r the ZACKLEES?"

Leroy: "Your face looks ZACKLEE like your ass"
ZACKLEES by SLic-Pi March 2, 2023