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Whatisitis 

A life threatening disease that can be contracted through excessive existential questioning. Some symptoms may include depression, substance abuse, social withdrawal, identity crisis, and a shitload of other dysfunctions. Although deadly, this disease can be cured with a large dose of distraction, available in both physical and mental forms.

Please note that even after a person has recovered from Whatisitis, it will never leave the body of the carrier. It is, however, non-hereditary. You can also attempt to spare your children the uncertainty of life by introducing them to extra-curricular activities and/or by brainwashing them.
You: What is that? *squinting*
Me: What is what?
You: What is THAT? *points to object in distance*
Me: What is WHAT? *using air quotes*
You: No, I'm serious.
Me: What is serious?
You: Ugh.
Me: What is ugh?
You: *thinks harder* Holy shit my brain is on fire... stop.
Me: What is stop?
You: *catching on now* What is is?
Me: What is what?
You: What is what is?
Me: Damn, I don't know what anything is anymore.
You: Me neither.
Me: Sorry for giving you Whatisitis. Then again, why am I speaking? Nothing makes sense! What is speaking and what is sense?!
You: Wanna smoke up?
Me: What does that mean? Oh fuck it, where's my bong?
Whatisitis by strawberryweedles April 12, 2010
Related Words

whoritis 

Very Contagious disease can be contracted from fat sluts one of three ways
1. Sexual Contact
2. Being Whipped by them
3. Getting within a 5 foot radius for prolonged periods of time.
1. The fat bitch must have gave me whoritis.
2. I can't breathe the whoritis is acting up again.

Whipitis 

A disease that effects the hip region of an otherwise attractive female. This female has extremely wide hips so much so that they take a stunning woman and make the male species not want to reproduce with her. She is fantastic looking from the waist up but from the waist down she is a beast.

W(ide)HIPITIS
Evan: Look at the hot girl sitting over there
Eric: Are you kidding?
Evan: No she looks amazing
Eric: Dude, when she stands up you'll see that she has the worst case of Whipitis I have ever seen, stand clear.

"That girl over there has a severe case of Whipitis"
Whipitis by Whipitis Expert May 19, 2006

Whoritis 

The non-clinical disease relating to women who have the compulsory need to engage in sexual intercourse with any male. Women with this disease often have sexual intercourse with random men at least once per day.
Man: She has so many STDs. I think she may have whoritis.
Phrase who is it with no particular reference to WHOIS in IT
Admit to submit whoisit site @yourownperil.
whoisit by Hercolena Oliver March 28, 2009

Whoritis 

A disease in which u r a complete whore
Kat has whoritis.
Whoritis by Crazy little hoe May 18, 2015