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SYFFUF is short for "Shut your fucking face, uncle fucker", a commonly used phrase in the USA. It was introduced in 1890 by Pope Gregorius XIV but gained popularity when Matt Stone and Trey Parker used it for a song in their popular television series "South Park".
Aunt: "Bob, you suck!"
Bob: "SYFFUF!"
SYFFUF by Burn666 January 17, 2008
Related Words
SYFFUF syff syffer syffu
<CraBYbebeq> u WÝLL die while u r sexing and speaking abt SEX...omg GET LOST THE WORLD!!
<Requiett> Syffu.
syffu by Requiett November 13, 2004
Syffer (adjective)

Syffer is a happy yet depressed person
E. g. I'm feeling syffer today
syffer by -Nay May 13, 2018
An abbreviation for the term "Shut your fucking face uncle fucka"
Terrence sent the text "syffuf" to Phillip
Syffuf by SUPERWOGFAN100 September 7, 2025