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One hole babe 

Aka shemale.

Only has one hole in the nether region. Missing a vagina, still has the penis attached.
First Guy: "Wow man, she's hot!".

Second Guy: "Dude, she's a one hole babe!".
One hole babe by Reppy May 23, 2008

playing the one-hole skin flute 

she loves playing the one hole skin flute

Two Boobs, One Hole 

The belief of the heterosexual minimalist that reduces the importance of aesthetic appeal during intercourse. Simply put, the belief that any woman with a pair of breasts and a vagina is more than sufficient for having intercourse. Also known as "I take whatever I can get".
Jim: "Dude, that girl is fugly as hell. I dare you to try and get with her".

Bob: "Sure, I don't care. Two Boobs, One hole, thats all i need".

Jim: "You're a freak, man."

In one hole and out the other 

Giving a blow job through a glory hole whilst taking a shit
The stench was pretty brutal in stall 3 when the snake wizzard was in one hole and out the other. He sucked me dry and dumped his stinky load simultaneously. Febreeze anyone?!

Too many dicks in one hole 

Redundancy, six guys doing a job that requires just one guy. You could also consider this a form of clusterfuck.
I've got 6 guys painting a single 4 x 8 sheet of drywall. Talk about too many dicks in one hole...this is a clusterfuck!

One Hole Wonder 

When you fuck a girl so hard in the ass you split the skin between her ass and cooch and she becomes a one hole wonder.
Dang, those 5 guys fucked alisha so hard in the ass they gave her a one hole wonder.
One Hole Wonder by turkeyyummay February 15, 2009