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Reference to Tuscaloosa, Alabama -- the official college town of the University of Alabama.

Also doubles as the other Tuscaloosa, Alabama nickname (as it relates to the University of Alabama football program's all-time, NCAA-leading 12 national titles): Title Town.
"This year, Bama plays Auburn at Bryant-Denny, so the Barners will get their asses kicked in T-town."

"Winning 12 national football titles -- which is more than any other school in the country -- warrants calling Tuscaloosa Title Town (T-town)."
T-town by Stays Crunchy In Milk February 28, 2009
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Tulsa.
Tulsa was originally named Tulsey town when it was founded back in the 19th century. It was given the nickname T-Town, and later, by the time it was an official city in1897, it's name had already been changed to Tulsa while retaining the nickname T-town.
"We're going from OKC up route 66 to T-Town."
T-town by mazeppa May 8, 2009
An abreviation for any village, town, city, or populated area whose legitimate name starts with T. Often used by youth to make their current location sound more "street".
I live in Tacoma, WA - T-Town.
My friend lives in Toronto - T-Town.
T-Town by Mad_Rhetoric October 4, 2005
Let's all go to T-Town!
T-Town by Poguezilla May 2, 2008
referance to Tulsa Oklahoma. used mostly in the punk/rock/music scene.
"Crowd Chant: T-Town! WxC!"
T-Town by T-Town WxC. March 30, 2009
ya'll wrong t-town is tacoma, wa, straight up
watch ya mouth when you talk about that t-town
t-town by schelene April 27, 2005
Slang term for Tucson, Arizona
What are we doing in T-Town tonight?
t-town by Colin August 19, 2004