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Most commonly found in nerds/geeks and is an extreme over reaction to any form of assessment in which they can study for

Nerd: "My brain is about to explode... I have been studying all day."
Random: "Dude, you need to find some medication for your serious case of OSD!"
OSD by non_stop.dance_party September 2, 2010
Over Sized Dick
"Did you ask me if his dick was small; it was an OSD girl"
OSD by beenjordansince December 23, 2014
I Just Bought A New Pair Of Shoes Man - Jerry
Dude, You Have OSD. - Emanuel
OSD by Julio Boss 415 September 29, 2008
OSD is anachronism for Obama Slobber Disorder: Used in a derogatory way to describe one who can not see Obama’s flaws due to their “slobbering” love affair with the man.
You OSD blinds you to the President's Socialist agenda.
OSD by oramato March 31, 2010
Osgood-Schlatter disease (OSD) is a common cause of knee pain in growing adolescents. It is an inflammation of the area just below the knee where the tendon from the kneecap (patellar tendon) attaches to the shinbone (tibia).

Osgood-Schlatter disease most often occurs during growth spurts, when bones, muscles, tendons, and other structures are changing rapidly. Because physical activity puts additional stress on bones and muscles, children who participate in athletics — especially running and jumping sports - are at an increased risk for this condition. However, less active adolescents may also experience this problem.

Painful symptoms are often brought on by running, jumping, and other sports-related activities. In some cases, both knees have symptoms, although one knee may be worse than the other.
Knee pain and tenderness at the tibial tubercle
Swelling at the tibial tubercle
Tight muscles in the front or back of the thigh
Hey man, Did you hear David has OSD?”
“No bro, but I think Ashley has it too!”
OSD by MaddiOkay May 25, 2019

OSD - Obsessive Smiley Disorder 

Kinda self-explanatory, its using a shit ton of smilies in every single one of your conversations online/texting.
=) =P 8D =0 =( =\ ^.^ ^.- <----this person has OSD - Obsessive Smiley Disorder