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As said by J-Roc on "Trailer Park Boys", a mafucka is the urban bastardization of motherfucker (q.v.) however its use can vary widely, see example:
"Game's postponed because no mafuckas can go to Canadian Mafucka and get a new orange mafucka for $2.99 !?"
mafucka by J-to-the-R-O-C September 1, 2005
Related Words

Mowfucka 

black slang term for mother fucker.
Was discovered in east compton outside a kfc.
Is pronounced the way it is due to blacks cant pronounce

syllables.
Damn that guy ripped me off. What a mowfucka!
Mowfucka by Theanalbaby May 26, 2009
Indian Person - "You maufucka!'
maufucka by DigitalMasterDX July 21, 2009
I'm finna get in this mafucka ass
mafucka by duse February 28, 2005

Mahfucka 

I'ma kill that mahfucka if I see him again!
its like saying motherfucker but you are saying it like Kiki from Vh1's Real Chance of Love 1 and Charm School with Rikki Lake. Maufucka (Mow-Fucka)
Me: Kiki shut the hell up!!
Kiki: Maufucka i will shoot you in your face!!!! Grrrrrr!!!
maufucka by Loismustdie2009 August 19, 2009