Example:
Spencer: "Hey Eric, do you want to go to Books-A-Million?"
Eric: "Fuck no, that's ghey, you fucking ghey!"
As opposed to when it is used in the literal sense.
Example:
Spencer: "Hey Eric, Raj and I are going to go have
anal sex and cum all over each others' balls, do you want to join in?"
Eric: "Fuck no,
that's gay, you fucking gay!"