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Significant Friend 

An amalgamation of "Best Friend" and "Significant Other", usually referring to someone of the opposite sex. Essentially someone who you have no romantic connection to but still love (as a friend) anyhow - a step above "Best Friend" which is used too interchangeably with "Friend".
You know, you're not just a friend Alyssa, I'd call you a significant friend :-)

significant nother 

1. that other someone that a person in a relationship is diddling on the side; the dirty mistress, if you will.
2. synonym for the "free-pass fuck," that hot person or celebrity you would want to do and not have consequences while in a relationship.
Yeah, David is my boyfriend, but Harry is my significant nother.

Oh, yeah, Kevin knows that if Jake Gyllenhaal comes to town, he better not come back to the room, cause Jake is my significant nother.
significant nother by Siena K February 23, 2008

Significant other 

A person, and or; persons your in a sexual relationship with no strings attached!!
I have a significant other
Significant other by Datmeat April 1, 2020

significant event 

Noun. Anything that comes in the form of a phonr call or text. The receiver that is made aware of the significant event does not make any verbal reaction. Rather, upon receiveing the phone call/text, their face becomes nervous and is followed by a series of 2 to 7 twitches of the left eye. The person then proceeds to get their ass off the couch and takes action.
(text of significant event): Dude, sum grandpa jus jacked ur Camaro from outta ur driveway.

recipient: (Twitches, stutters, and bolts out the front door)

Significant Ear Damage 

Commonly abbreviated as SED, Significant Ear Damage is genre of music created for Zac Seif's music, specifially a song called "I can't survive," because even Emo is not terrible enough a genre to categorize his music as.
Guy 1: Did you hear Zac Seif's new song? It's the best example of Significant Ear Damage music out there!

Guy 2: Thanks for the warning, I'll be sure to avoid it!

Significant ex

The person who was part of the most significant or meaningful relationship that you used to be in, but aren't anymore. You can have more than one ex, but you can only have one significant ex.
The other day, I ran into that guy/girl I went out with for a little while and it was pretty akward. Glad it wasn't my significant ex at least!
Significant ex by Shmooboo March 27, 2015