Downer 

a person place or thing that has down syndrome or looks acts or dances like a retard.
usually lacking their full 46 chromosomes.
Often used by Marina and Laura

"look a Fred, hes such a downer"

Downer by C-Downer-Breezy May 29, 2009

Downer 

Someone who feels unloved, because the universe does not love her and never did.

Yo, dang, jew smoke son peyote an shit? Wutcha making yo mama a downer for dawg?

Downer by sulumor July 12, 2016

downer 

boy with a head falling to the side

hey steve, bryan hendersons such a downer

downer by the guy in english January 20, 2010

downer 

rehabilitating druggie

a smack head who is currently off it ie a downer

downer by jjjjji September 29, 2010

downer 

another way of saying a drink because you down the drink

"man its hot out here i need a downer"
it is NOT used like "what downers will everyone be having this evening"

downer by finn peters November 29, 2016

Downer 

Drug that acts as a central nervous system depressant, most often used to describe opioids, benzos and alcohol.

"hey dude, you got any downers?"
"i got some xanax and oxys, what you want?

Downer by PsychodelicJesus March 26, 2023

downer kebab 

the fact of eating a kebab (i.e. Turkish dish) you've been craving for after a night of heavy drinking and it turns out it's not good at all and ruins your mood.

Mike: we went out last night and had lots of drinks.

Steve : it must have been fun!

Mike: the drinking was ok, but then we had to drink and had a downer kebab. It made me sick the next day.

downer kebab by El_Gringo_from_Van March 28, 2013