what's up your butt Share definition Flag It basically means: "Why are you so mean/angry/salty today?" In my understanding... "Go away," he said angrily. "Jeesh! What's up your butt today?" what's up your butt by Can_u_not April 18, 2016 0 0 Get merch Get the what's up your butt mug. Buy Now — $32.95 See more merch