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Gay reference to anal sex after drinking. To put your cock in the tail. "Hey, lets go cocktail after the bar."
Hey, let's go to the bar and then cock tail later.

My asshole is so sore from cocktailing last night.
Cocktail by MeliJ November 19, 2015
A combination of drugs, usually three or more, for HIV treatment also known as HAART (highly active antiretroviral therapy)
Debbie: So how long you've been positive, Ben?
Michael: Mother?
Debbie: Is just like to know.
Ben: That's ok. I'm fine with that. 5 years.
Debbie: What your T-Cell count?
Ben: Six hundred.
Debbie: Even been hospitalized?
Ben: No not yet. he knocks wood Not would.
Debbie: Viral load?
Ben: Undetectable.
Debbie: On the cocktail?
Ben: Anti-virals.
Michael: What the fuck you think you're doin'?
Debbie: This is the reality, sweetheart. And you're just gonna have to live with it.
Cocktail by Virg1l July 30, 2009
when your erect dick (cock) is halfway in your sex partners anus there for looking like they have a cock for a tail
"when i walked in on u and that chick last night it looked like she had the biggest cocktail"
cocktail by Brandon Matte January 20, 2008
I'm going out tonight, gonna get me some cocktail!
cocktail by Chris Kirk July 25, 2008
a cigarette with multiple drugs (especially illegal or ill prescribed one's)
That cocktail is sure to hurt later on.
a cocktail is a blunt,or joint laced with crack cocain
man you want hit this cocktail an get the nummy lips.
cocktail by mr wizz 89 December 29, 2009