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Stands for Best Friends Forever. An abbreviation mostly written on binders or notes by girls in grade school, however, over the last few years, people who use to use the term in grade school have actually started saying it, typically in a joking manner, to mean a close relationship with someone.
OMG Wendy is so cool, we are totally BFFs now.

We have so much in common, its like you are my BFF.
BFF by evapor8ed July 29, 2008
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I like a lot off BFF.
BFF by Whyyyyyyy Cruel World December 28, 2017
Related Words
BFF BFFR BFFL Bfff bffe bfffl bffn BFFAE bffb bff jill
for some reson BFF is the acronym for Best Friends Forever.
but don't it look like 'Best Fucking Friend'? i think so.

BFF = Best Fucking Friend

B = best
F = fucking
F = friend
"dude, you rock! you're the bff (best fucking friend) i've ever had!!!"
bff by Queen of the Underworld September 22, 2006
Means Big Fat Friend, Big F*****g Friend, Big Fat Female, Brown Flowers Friends, ex...
Hey! Look it that BFF!
Yeah, he's a f***er!
BFF by Jaemins Pink Hair October 16, 2019
Best Friends Forever.
(a) {in magazines} used as 'best friends' because they can't write bf cuz thats boy friend, and theyre too lazy to make grammatical sense of it..
(b) Something random to say at the end of an email - but really, who uses e-mail anymore when you could 1) use the P-H-O-N-E, or 2) Hello? Instant Messenger?!?
(c) Yearbook
(a) My bff's bf Bradley F. is going to the mall today. = My best friends forever's boy friend Bradley F. is going to the mall today.
(b) Talk to you later ;) BFF
(c) You rock don't ever change! BFF!
BFF by Bambam_For_Flinstone December 31, 2004
BFF is the ultimate sex routine: (1) Blowjob, (2) Fuck, and (3) Facial.
"What do you feel like doing tonight honey?"

"BFF!"
BFF by monsterjerk August 24, 2011
a) Typically it means “Best Friends Forever.”

b) After seeing numerous dental hygiene patients NOT flossing daily, a male hygienist in WA state one day (mid-September, 2011) came up with a fun way of incorporating “Flossing” into people’s daily routine. He believes doing three things daily---“Brush, Floss, and Fluoride” will decrease the chances of getting cavities and gum diseases, will save a lot of money for his patients (not having to spend money to fill the cavities) and will make people happy, hence BFF (Brush, Floss, and Fluoride). Eventually he wants everyone to have the habit down and that should be everyone’s Best Friends Forever.

c) He gets a lot of chuckle from his patients over this new twisted definition and enjoys seeing his patients motivated to do BFF daily.

d) He expects to see a lot of Thumbs-up after this post. People who click on Thumbs-up agree with him and will Brush, Floss and do Fluoride rinse daily to keep their gums/teeth healthy.
Hygienist: Hi Linda, how has your Best Friends Forever (=Brush, Floss, Fluoride) been lately?

Patient: Haha...Well, I’m doing well with Brushing 2-3 times a day, but Flossing could be better. I use Fluoride rinse a few times a week for the past several months, and it seems to help with my sensitivity.

Hygienist: Well, it sounds like you’re doing much better than the last time. Keep on working on your BFF. That will be your Best Friends Forever! :-)

Patient: Thanks. The BFF thing really helped me to remember to do all three daily. My gums don’t bleed as much as it used to.
BFF by WA RDH September 27, 2011