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no issue no tissue 

Not sure how this has no definition yet and generally isn't a more common used figure of speech, because it works in multiple ways.
So, basically

1: If you don't spill anything on the floor, you're not going to have to clean it up
"Can I trust you to work alone for a bit?"
"Yeah bruh, no issues, no tissues"
2: If there's no problems, then you don't need anything to wipe the tears out of your face

"I'm fine"
"You been crying, no issues no tissues sis"
3:

A way to respond to someone inquiring requests from you that you currently don't have any
"Dude, should I get you anything from da store?"
"No issues, no tissues homeboy"

4:
When someone expects one of your experiences to have been way more intense than they really were

"Fell down de stairs"
"Ahh shit musta sucked homie"
"Nah brotha, no issues, tissues"
Look above cunt
No issue no tissue
Ya happy urban dic
no issue no tissue by Petra Jansen November 10, 2019

tissue but no toilet blumpkin 

When you are craving for a blumpkin but there is no dam toilet near u an ur bitch go behind any hiding public place with no toliet and you get on your knees an she gives u a blumpkin while neiling and taking a ferocious shit an den cumming all over her face an let it dry an ripple just like tissue
"tissue but no toilet blumpkin"
allright say ur name is rhys an u love to give blumpkins u go with ur man or girl an give dem a blumkin cause der is no toilet