tweakwhore Share definition Flag like a crack whore but for meth, most tweak whores give good head because they don't have teeth. most tweakwhores give good head because they don't have teeth or that tweak whore does anything for more tweak. tweakwhore by lotuslord December 31, 2014 0 0 Get merch Get the tweakwhore mug. Buy Now — $32.95 See more merch