To drink such a large amount of alcohol that you start to destroy chromosomes.
'Man, I've got ten cartons of beer, four bottles of tequila, seven magnums of champagne and a flagon of wine. Lets get retarded!!!!'
Something you say when an in-bred redneck asks you the time
In-bred redneck: "What's the time on that there portable counting clok you is wearing?"
You: "Stupid o'Clock."