I believe this term originated in the Animated Television Series "The Simpsons"
Edna: Embiggens? I never heard that word before I moved to Springfield.
Ms.Hoover: I don't know why. It's a perfectly cromulent word.
To have ones mind scrambled or acid addled, under the effects of hardcore psychedelics.
"Where's Tiny Tim?"
"Don't even bother trying to get an answer outta him, he's as fruited as my Nans mince pies!"