Definitions by Mentis Debilitatum

47 chromosomes

Also known as trisomy 21, or Down syndrome - a genetic defect that leads to retardation and other mental disabilities.

"Mitch is a fucking mental midget with 47 chromosomes, screw him!"

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A severe case of retardation, usually seen in bronies and weeaboos.

Damn, Mike probably has mental cancer from watching all these MLP music videos.