An insulting nickname for a girl whose name ends in issa or essa (Melissa, Alyssa, or even Vanessa). Normally used to describe a girl who displays male features, also used to describe a transvestite.
Peter: Did you know Manlissa squat 300lbs?
John: Its no suprise, I heard Manlissa has to shave her beard everyday.
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Transvestite: What's your name baby?
Jacob: Eww, leave me alone you Manlissa!