Somewhat of a generic term to describe any ailment (typically gastrointestinal in nature) you may be having at the time. Often used in conjunction with "blowhole", as a combination that just sounds good together to complete the sentence.
Dude you don't look good..... you look like you're coming down with farfilosis.
A serious but curable condition in which a person has not had pizza to eat for an unacceptable, extended period of time.
Order me that pepperoni pizza will ya.... I have a serious case of hypopizzeremia