1 definition by Dr. DontDoIt

Speedball- An IV injected mix of heroin & cocaine. This is one of THE most dangerous 2-drug combos known. Speedballing is most often done with the mixture of both drugs in one syringe that's injected. Speedballing not only has a high mortality/death rate, but loss of limb and other problems can arise.

Some inject each drug separately, often a syringe of heroin injected in one arm (or any where else they have a good vein- groin, leg, etc) immediately followed by an injection of cocaine. Sometimes people will shoot (inject) one of the drugs, while having someone else simultaneously shoot the other. Rarely, the Speedball mix is snorted instead of injected but the high is said to be less intense, as IV drugs are usually more potent than snorted drugs, but it's still highly dangerous.

Speedballs are said to cause 1 of the strongest highs... if you live through it. Mixing this upper (cocaine) and downer (heroin) is suppose to counteract some negative effects of the drugs, while also causing an extreme rush and a euphoric high with the "good" effects of both drugs, including the dangerous ones. Contrary to popular belief, Speed, Meth Amphetamines, and other drugs are not used in Speedballs. Historically many used morphine or other opiates instead of the heroin, but most people don't consider this a "true" Speedball now. Some mix benzodiazepines (Xanax, Valium, Klonopin, Ativan, etc) & amphetamines and call it a Speedball, but again this is not considered a true or real Speedball.
John Belushi, River Phoenix, Chris Farley, Jean-Michel Basquiat, MLB Player Ken Caminiti, Pete Farndon, Zac Foley, Chris Kelly from the group "Kris Kross", and Eric Show are just a few from the long list of celebrities who died from doing Speedballs.
by Dr. DontDoIt January 25, 2014
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