That's whats up 

Used to agree with something, To say you like something, When you don't know what else to say, and when you don't know how to answer a text.

-I'll be there later.
-That's whats up.

-So, I'm bored.
-That's whats up.

-Wanna get burritos?
-That's whats up!!

That's whats up by I'mwhatsup(: February 11, 2010

that's whats up good lookin out 

1. an expression of approval and thanks for a good deed, OR, 2. can be used in sarcasm to show disinterest in someone's actions or feelings

1. Miss Utility: "I'm not wearing any panties."
Tito: "That's whats up good lookin out!"
or
Danny: "I got laid off today. I need to look for a new job."
Tito: "That's whats up good lookin out?

that's whats up good lookin out by goose smacker March 1, 2009

whats up with the D.S. 

a phrase refering to the pleasuring of the male genitailia orally by a female with rather large breasts or a dubble bubble.

marie got down on her knees when john said " marie, whats up with the D.S.? "

whats up with the D.S. by Jo Von teh H4xOR June 18, 2006

what's up checkmark 

A reply made by youtube commenters when a verified youtuber leaves a comment on someone else's video

Youtuber: Great video, man!
Reply: what's up checkmark

what's up checkmark by Redthetroll May 16, 2021

What’s up G 

A slang way of saying hey or what you doin

Guy#1- “YO what’s up G”
Guy#2- “Nothin, just chillin”

What’s up G by Yo G from the hood May 12, 2019

What's up, doc? 

A very famous quote from Bugs Bunny.

*Bugs Bunny gets out of his rabbit hole*

Elmer: Ahh! Wabbit!

Bugs: *chews a carrot* What's up, doc?

*Elmer freaks out*

What's up, doc? by Keapon Laffin May 3, 2010

what's up with that

A phrase used to ask about something odd, or what the point of something is. The word "that" can also be replaced with whatever noun the person is asking about. It is also common to inerject the word "fuck" into the phrase to express shock or discust.

What's up with the smirk?
Look at all those bags on the road. What's up with that?

Person1: What the fuck's up with your hand!?
Person2: Ahh! Why are you just standing there?! Take me to the fucking hospital!

what's up with that by Cinymin86 November 16, 2009