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To be in a combined mental state of tired and wired.
I see my colleague in the elevator on the way to the meeting room. I ask him how he is doing. He says, "I have been up all night to prepare this presentation for the board. I've been working on it non-stop for three days. I've been drinking coffees like a bandit to stay awake. I'm so toasted. I'm so wired, too. Man. Hell, I''m twired.
Twired by Royal Wulff November 27, 2012
Related Words
Being so tired that your body tries to make up for it in a ridiculous level of stupidity. The result is an a very hyper (wired) person that you need to convince to sleep.
Twas the night before the exam, and the student was twired as all hell.
Twired by JJ Rylee October 24, 2016
A Twitter user who follows someone without any readily apparent reason.
@tweirdo1 Hi. Who are you? Why are you following me? I just made my Twitter account SECONDS ago.

@twierdo2 Hi. You're the second person who wants to follow me without knowing who I am. I have dubbed you both "Tweirdos."
Tweirdo by Ancient Weirdo July 23, 2012
Tired, Wired and Weird. Usually a state of being after a significant period of partying.
We are going to be hella tweird after this weekend.
Tweird by myco2012 October 8, 2011
It's a point where you are so far past tired you are hyper
I am so Twired right now
Twired by Lossy love 9213 May 11, 2016
The hyperness a person experiences when exhausted beyond wanting to sleep. resulting in a high levels of stupidity and impulsiveness. Generally caused by stress of alcohol.
Twas the night before the exam, and the student was twired.
twired by JJ Rylee October 24, 2016