Making uncontrollable body movements or spasms after the consumption of marijuana
Evan: "Woah dude, I'm tweeking so much"

Nick: "I could tell, your legs have been moving every five seconds"
by SpareChange November 25, 2011
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Gay. Twitchy. Spaz. Loves Craig, Kenny. An adorable bean. GAH!
“Oh my god, Tweek and Craig are holding hands” gasped a random person on the street
by ThatSouthParkYaoi July 1, 2018
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A character from the T.V show "South Park". He has very messy blonde hair and supposedly sufferes from A.D.D but his twitching and nervous personality is due to the large amounts of caffeine he consumes. In Series 6, Tweek became the main characters replacement for Kenny, alongside Butters, after he "permeanantly" died at the end of the previous series.
"Tweek's the worst character ever."
"Yeah. Worse than Towelie."
by Issy Aidsfunop January 15, 2006
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to be overly excited at a situation or event that is highly positive and causes exuberance beyond classification of excitement.
Scott won a vacation to Hawaii, a place he always wanted to go, causing him to call his friends and tweek.
by BT14 July 30, 2007
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When a person who calls himself a business manager, steals people’s money, is paranoid from 15,000 dollars of crack in a burnt stem.
James Nicols was tweeking off that 15,000 dollars.
by Jaythereal December 22, 2022
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