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Verb. A side effect of extreme over indulgence in crystal meth or crack cocaine. Tweekers typically perform OCD-like activities centered around finding small quantities of drugs that were inadvertently "misplaced". Tweekers may be seen on all fours, searching in gutters, obsessively looking under various objects and so on. In certain circumstances, extreme tweeking resembles autism or catatonia.
Yo! Check out that tweeking crack ho!
by Slagathor April 23, 2004

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A character from the TV show "South Park". Tweek is the ADD kid, who is constantly twitching. He often rants and raves about things that only he sees, and is addicted to coffee. Tweek is in love with Craig, and they sex each other.
Wow. Tweek sure has sex with Craig a lot. It's hot.
by The Lord Of Spam February 16, 2006

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losing oneself in a senseless task while under the influence of speed.
She would tweek all night cleaning the house and pulling apart electronic devices.
by chillcat May 29, 2003

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the nervous ticks or twitching one experiances as they come down from a crystal methamphetamine binge.
pulling hairs out of their face; picking at their face; picking their nose...
by a former tweeker November 28, 2003

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Upper, crystal meth
can I have a bump of tweek?
by Cosmo Wash.DC December 26, 2002

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to adjust or fix
Let me just tweek your computer.
by Tracy Lukeman October 20, 2003

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To be high and see something that is not not present.
I was driving around I started tweeking , I thought I seen someone on the road
by URBAN HOODS January 19, 2015

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