50
Someone who Messes around with more than one person.
Christina had sex 5 Guys Last Night. She is Such A Tweaker!
by Mizzjas1802 October 13, 2010
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51
Keeth, Johnny Ray and Tim. Not Tweaker Dave any more.
Keeth, Johnny Ray and Tim are fucking tweakers but Tweaker Dave isn't a tweaker anymore.
by Kevin Twisted April 09, 2005
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52
by Jared Blash September 22, 2008
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53
A druggie, a not sane person, an idiot, a person who punishes another person unfairly
Student: *FART*
Teacher: Go to the office
Student: Thats not fair, you're a tweaker!
_______

Tommy: Hey, Joe, look at John today, he's like high or something!

Joe: Man, he must be a tweaker!

_________

Crazy guy: Look at the flying donuts!
Insane asylum guard: My god, he is crazy!
Insane asylum guard 2: Man, he's a tweaker!

by Nerfer9 April 27, 2009
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54
being a dumb ass
jim your a fucking tweaker you know that
by tweaker101 July 19, 2010
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55
A female who has sex with a whole lot of guys and has no care of doing so.
She was at my house yesterday and now she's with my homie, I told him she was a tweaker.
by Geminibul23 January 19, 2011
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56
1 A thing you hold and point at the t.v. to change channels.
1 'Oh no, it's Mandelson (or other politician of choice), pass the tweaker quick.'
by Sue d'Aunim December 06, 2009
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