look up any word, like lemonparty:
 
29.
a girl thats always wanting to get it in
that freshman be tweakin all ova the place. this is her fourth abortion
by yolandaishurr January 28, 2011
 
30.
People that love to have sex. Someone whose always horny.
YO I HEARD SHAWTY RITE DERE A TWEAK!
by robbyfhark July 29, 2010
 
31.
v- to tweak
to be extra twitchy, secretive, giggly while under the influence of weed, pot, marijuana
to have the tell-tale signs of being high (squinty eyes, blood-shot eyes)
"Yo after taking those five rips off the bong, I was totally tweaking out. I was pulling my hoodie all the way down, I put sunglasses on, and my eyes were BARELY open"
by bnell9002 November 10, 2005
 
32.
Computers: To slghtly alter various settings and configurations for customisation and improving performance.
You can get better framerates in the game if you tweak some settings.
by generic January 21, 2004
 
33.
Someone who overly acts weird, reacts in a weird way, or acts unnormal and squarish.
When a teen acts too excited in class and starts tweaking out.
by magsoldier15 January 20, 2011
 
34.
To drink obsurd amounts of whiskey, vodka and beer....then throw a entire bottle of hot sauce about a residence room and in a couple peoples eyes, then passout and have a seizure in the middle of the kitchen....decent
Kevin Tweaked and emptied a bottle of hot sauce about the room
by Tweaksauce May 13, 2010
 
35.

1. to adjust slightly

2. to adjust a computer program slightly
They tweaked the game to fix a glitch.
by Light Joker August 25, 2007