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To injure slightly, to sustain a slight injury to (some part of the body), usually while playing a sport.
"The pitcher tweaked his groin on a grounder back to the mound."
by RB Jr. July 18, 2006
36 19
v- to tweak
to be extra twitchy, secretive, giggly while under the influence of weed, pot, marijuana
to have the tell-tale signs of being high (squinty eyes, blood-shot eyes)
"Yo after taking those five rips off the bong, I was totally tweaking out. I was pulling my hoodie all the way down, I put sunglasses on, and my eyes were BARELY open"
by bnell9002 November 10, 2005
13 13
Computers: To slghtly alter various settings and configurations for customisation and improving performance.
You can get better framerates in the game if you tweak some settings.
by generic January 21, 2004
10 10
Someone who overly acts weird, reacts in a weird way, or acts unnormal and squarish.
When a teen acts too excited in class and starts tweaking out.
by magsoldier15 January 20, 2011
0 1
To drink obsurd amounts of whiskey, vodka and beer....then throw a entire bottle of hot sauce about a residence room and in a couple peoples eyes, then passout and have a seizure in the middle of the kitchen....decent
Kevin Tweaked and emptied a bottle of hot sauce about the room
by Tweaksauce May 13, 2010
1 2

1. to adjust slightly

2. to adjust a computer program slightly
They tweaked the game to fix a glitch.
by Light Joker August 25, 2007
9 10
1. To prefect something
2. Used to replace cool or related words in a sentence as an adjective

1. I totally tweaked my kickfilp today
2. Man thats party was tweak as !
by Ev-Dawg October 02, 2007
2 6
to fucking snap! to feel like you have been through enough bull shit and you just want to hurt someone
my girlfriend was putting me through so much shit last night i was ready to fucking tweak
by Kevin Bowen September 11, 2007
4 8