Used in reference to the prescription cough medicine brand Tussionex which contains hydrocodone. Often mixed with a flavored beverage before consumption, which is referred to as syrup.
Tuss is the perscription cough syrup, that is purple, yellow or orange. This stuff fucks you up and make you sleep like baby.
Sippin Tuss started out in Texas and has grown in popularity all around the country. Some idiots think that Robutussin and tuss are the same thing, trust me they are not. You cant buy this shitover the counter.
"Drinkin Robutussin and Nyquill and calling it Tuss is like taking a tylenol and sayin its a x pill."