a zit or pimple with pus in it. Breaking your pustule is the same as popping it.
Bevis: Joe finally broke his pustule
Butthead: Really?
Bevis: Yea, he finally popped that enormus pimple on his forhead.
by December 26, 2006
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"Pustulence" is a combination of 2 words (like "smog" is from "smoke" and "fog"). "Pestilence" (a devastating epidemic disease) plus "Pustulation" (the state of having pustules - pus-producing elevations of the skin).
In David Lynch's Dune, Baron Vladimir Harkonnen found pleasure in his own pustulence.
by Mike Baker August 23, 2005
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Noun: A hard disk shaped crust of fecal matter that forms in the anus after each defecation. This is an extremely important part of a bowel movement in that it keeps ones anus from constantly leaking liquid shit. This disk shaped piece of shit acts as an anal dam but it can be broken at great embarrassment to the host of the anus. Wrestling, Yoga and/or laughing too hard can all cause enough stress to rupture a pustule.
Did you see that trail of shit? Beirne must have broke his pustule.
by Randy Sack JC November 4, 2009
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Full of pus. As in a a face ravaged by acne.
The pustulent creature emerging from the dark was a horror to behold.
by Baby Hughy November 30, 2004
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Small scraps of marijuana that are left over after the rolling of a joint and/or packing of the bowl.
Hey, Mocher, I rolled some joints in my car and now the front seat is full of pot pustules.

or

Big Daddy: Man, I wish we had some smoke.

Convoy: Yeah...

Jim: Man, when I think of all the Pot Pustules I've wasted, I'd have like a bunch'a joints and shit.
by RollUmBigged July 7, 2010
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A person that is so horrific looking that no matter how shit-faced drunk you are at the end of the night you would never go home with them no matter what.
Oh God, look at that crusty pustule at the end of the bar, he/she had better not even try to talk to me.
by rommate s dirty girl January 12, 2010
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A person that is so horrific looking that no matter how shit-faced drunk you are at the end of the night you would never go home with them no matter what.
Oh God, look at that crusty pustule at the end of the bar, he/she had better not even try to talk to me.
by rommate s dirty girl January 12, 2010
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