a. Something that has the quality or condition of being unsavory or tainted.
b. A slander or offence against someone who is supposed to be one of your friends.
c. A person(s) who is/are sexually contaminated, with a high likelyhood of disease. The actual having of the disease is not important, just the likelyhood.
Example B: "Why'd you have to cheat at cards! That's polluted!"
Example C: "Dennis was with three chicks in the past 2 days. You know he's strung out and don't wrap it up! He's polluted for sure!"