To nuke someone is to get revenge on them by finding something so awful and embarrassing and disgusting about them and sharing it with gossipy girls and watching the damage ensue!
Markie was a little bitch and stole a girl from me just becaues I bought her candy, so I sent out a nuke on that retarded bastard and it worked. he won't get to rape any drunk freshmen anymore
by Name-42 September 10, 2006
to anihilate a region or country with a thermo-nuclear device, weapons which depending on the payload can kill between 3,000 and 20,000 people with the initial blast, and kill hundreds of thousands more over the next decade through radiation poisoning.
1. "MC Ian's example of nuke is a typically moronic statment. Detonating a nuke is a lose-lose scenario for all humanity".

2. "There are currently some 30,000 nukes on this planet, enough to kill all human, animal and plant life on earth forty times over. I'm glad some faggot thinks it's necessary to do that one day"
by Lazarus Ciccone April 23, 2004
The (fabricated) designer drug used in the 1991 movie, Robocop 2.
This drug was extremely addictive, and used to alter and control ones mood as one sees fit. It came in several varieties:

Red Ramrod
Black Thunder
White Noise
Blue Velvet

The most commonly used variety being the Red Ramrod.
This drug was popular due to it's strong effects and cheap price. Red Ramrod gave the user a constant high for one to two days before the effects wore off. This drug was designed by Cain, and a scientist named Hank.
Nuke came in a small pod with a needle on the end, and was injected directly into the jugular/neck. Depending on the exact type of Nuke used, effects would differ.
by Therindos February 04, 2006
When an excessive amount of semen is released during ejaculation.
"Hey man, how was your night last night?"
"It was pretty good, but my favorite part was when i nuked all over your mom's face..."

"Man last night i was wanking off, and i nuked so hard my toilet overflowed!
by BallsMan5 February 11, 2012
An extremely ugly woman whose mere presence is enough to make a normally ugly female look attractive
Hey, did you hear about Johnny.
Nah, what happened.
We were clubbing last night and he hooked up with a "nuke".
I have lost all respect for him now.
Yeah, I'm deleting him off my Facebook for some shit like that.
by Balls are cool April 20, 2011
A hook-up that is so intense, it's of nuclear proportions.

Variations: Nuke it out; Nukin'

Caking, smashing, nailing, boning, etc. all have similar meanings, but none can match the intensity level associated with "nuking."
-Bro, did you ever end up gettin' with that bitch last night?
-Dude. We nuked it out for the longest time, it was unbelievable. I'm gonna try and nuke her again later tonight...
-Shit, man...I saw you guys cakin but I didn't think you'd actually nuke her.
by garhcSD January 13, 2011
To overthink something, the way that a nuclear scientist would think about how to flush the toilet after having to wipe his ass with an entire roll of toilet paper.
"God damnit don't fuckin' nuke it man, just flush the damn thing!"
by free_refil July 07, 2005
To utterly destroy a kingdom in RaceWarKingdoms for profit, fun, or because the bitch pissed you off
Almo nuked me! OMGWTFBBQ

Krom has stealthily attacked Questo's kingdom destroying 1% of its assets.
by RWK February 12, 2005

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