mrs. thug Share definition Flag a classy woman/lady/girl who's a thug. meaning that she keeps her pimp hand strong and gets that doe $$. OMG that girl from myspace is such a mrs. thug with her scene hair and her brass knuckles neclace. mrs. thug by ashley horror July 9, 2007 0 0 Get merch Get the mrs. thug mug. Buy Now — $32.95 See more merch