Short for Method of operation. Latin form "Modus expeditione." Meaning what one certain person is most noted for. A certain look, way of doing things or even attitude.

There is no latin word operandi
Stan: "who do i know that likes drinking and hates zombies?"
Nate: "Man, drinking and hating zombies?! Add pirates and thats my M.O."
by Andrew Von Doom September 12, 2005
Refers to a member of the Black Peace Stone Nation. A Mo is an abbreviated form of the word Moorish which refers to a Moor (a person of African descent). This name was adopted by the Black Stones when Jeff Fort (Chief Malik) restructured the BPSN nation to follow after Islam, specifically the Moorish Science Temple Muslims.
What up Mo? All Well Mo! What'z good mo?
by 5 Star Elite January 21, 2008
Some one who is not related to you but is older mentally and is close enough to be your sister.
Sarah is My M.O.S
by Savage16 May 30, 2016
Slang for a homosexual- short for "homo".
"You have 15 Barbra albums? You are such a 'mo".
by Duncan January 28, 2004
A cool guy who always knows what to do in every situation. The complexity of his personality makes up for the simplicity of his name. He has many secret hobbies and is good at most things he does. Everything he achieves is a result of hardwork and passion.
Did you see that?

Dude, you totally went all Mo on his skinny white ass.
by Pro-mo February 04, 2010
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