Upset, to the point of anger.
A combination of the terms "pissed off" and "miffed". Alternate spelling: mift off.
The pretty young lady was miffed off after her boyfriend sent her on a pointless trip to the grocery store (in a driving rainstorm, no less) to buy some wheat germ.
A hardo is a person who tries extremely hard at everything. Most times a hardo will try very hard at things that do not require excessive effort. For example, sports practices, gym class, etc.
Wow did you see Jack at practice today? What a hardo!