Top Definition
Yet another slang term for womens breasts.
She's got some nice mcguffies
by Duncan August 22, 2005
The act of hurdling or jumping over one during a football game while carrying the ball.

Originates from Cy-Fair's running back Sam McGuffy.
Crowd: Ahhhh...
Player: -Jumps-
by K.Young March 04, 2008
to jump over someone when they wern't expecting it
During the middle of the football game a player pulled a mcguffy right over another player.
by fakeperson55 January 06, 2008
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