Boy from John Knowles's A Separate Peace. A recluse and continually scorned by the other boys at Devon for avoiding the war (World War II) Leper is like the punching bag and sad sack. Eventually, he succumbs to insanity after having to endure the harshness of training for war, never actually making it out to battle.
Brinker Hadley was one of Leper Lepellier's main antagonists, rejecting him because he feels he is too much of a "naturalist."
by I Have A Name But It's Secret November 10, 2009
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That group of kids everybody knew in high school that individually were often the targets of derision and/or physical violence, but who through some geek radar found one another to form an alliance, thereby lessening the probability that any one member is a victim.

The reference to the middle-age practice of isolating individuals with Hansen's Disease (Leprosy) and not allowing them to come into contact with any "normal" people is apropos because if a "normal" (read non-geekified) child were to associate with the leper colony, s/he is immediately labeled as suspect, and in extreme cases will be isolated him/her self, thus becoming a member of the colony.
Mark's sister: "Mark has been indoctrinated into the Leper Colony and is at the park LARPing."

Mark's mom: "NO GOD, NOOOOOOOO!"
by cowboythecat October 28, 2010
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Look at the way he is walking, you know he has got to be a leper prince!
by Solid Otacon June 10, 2015
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Someone who is so anti-social that if you hang around them a lot, you will find yourself becoming like them. Sort of like you caught their leprosy.
I used to be the biggest thing ever at this school. Then, I started hanging out with this social leper and now I have to beg for people to hang out with me
by Alex Pearson April 15, 2006
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Making love with his ego,
Ziggy sucked up into his mind.
Like a leper Messiah,
When the kids had killed the man I had to break up the band.
by Miki October 22, 2005
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someone who can ruin your status with others just by hanging out with you
Did you hear about poor Steve?
Who's Steve?
My point exactly. He is the football quaterback. Poor Steve met a social leper and now no one hangs with him anymore
by Charece April 25, 2006
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A Leper Supreme is the act of having sex with a leper (one who has leprosy) through new orifices, created by mashing soft, rotten parts of their skin with your penis. After banging several new glory holes into your unfortunate friend, one finishes the Leper Supreme by dipping a nacho chip into a gooey part of their head and eating it.
"Call Gary over, its time for a Leper Supreme."

"Oh lawd, Kerpal sure does love Leper Supremes!"
by TheBigfilthy April 30, 2009
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