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1.
The breeding of people/ animals/ plants that are closely related to each other (first cousins or even closer), thus keeping the genepool weak and leaving them vulnerable to various health problems, mentally and emotionally as well as physically.
Purebred dogs and royalty are notorious for inbreeding; to keep the line "pure" then they are only allowed to procreate with their "own kind", even when offspring are stupid, sickly, deranged, ugly or any number of things.

Carlos II of Spain was the end result of the Spanish Hapsburgs; his parents were uncle and niece and both were highly inbred. Carlos was deformed, retarded, delicate, and had an extended infancy and premature senility. He was married twice, but he was impotent and sex was beyond his abilities.

Plants can be inbred, too; bananas of today are very different from those of three generations ago and often lack the genetic diversity which would keep them healthy.
by Loreleili January 15, 2011
290 17
 
2.
The breeding of two animals who are related to each other.
Brother and a sister
by M February 19, 2004
68 23
 
3.
How graduates and fans of Auburn University (a.k.a Cow College, The Barn, Bama Poly, The Silo, Redheaded step-child) procreate.
EaglesKill05 practices inbreeding with his mother. The result is a child with huge ears, 12 toes, 8 fingers, and no balls.
by Roll Tide Roll October 20, 2005
24 196