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(1)As a greeting or as a farewell, to be used in general speak as a substitute for a much better, more difficult salutation.
(2) As a substitute for an affirmative response.
(3) As a substitute for virtually any interjection.
(1)Fred: I'll see you tomorrow, Chuck.
Chuck: OK Fred. Hizzoo!

(2)Fred: Are you going to the movies?
Chuck: Hizzoo!

(3) (A) Fred: Jeter just hit a Home
Run. Hizzoo!
(B) Fred: I won! I won! Hizzoo!
(C) Fred: Didn't that movie rock?
Chuck: Hizzoo!
Hizzoo! by Christopher Graham August 26, 2005
Related Words
noun; slang for hook, often found in the phraze "off the hizook"
This Rolls is off the hizook.
hizook by MC August 12, 2003
Hizook: Simply weird Ebonics term for hook. For those who enjoy such nonsense.
Gonna be off da hizook tonight
Hizook by Sardis February 15, 2006