e-tistic Share definition Flag A variation on "autistic". Describes someone who has become so used to e-mail that they shrink from more direct forms of communication. "Don't even bother calling Adam. He's gotten so e-tistic, he's afraid of the phone." e-tistic by rufus59 December 20, 2008 0 0 Get merch Get the e-tistic mug. Buy Now — $32.95 See more merch