The brand name of a type of household drain cleaner.
EXAMPLE:

' But now Midland City looked unfamiliar and frightening to Dwayne. "Where am I?" he said.

' He even forgot that his wife Celia had committed suicide, for instance, by eating Drano --- a mixture of sodium hydroxide and aluminum flakes, which was meant to clear drains. Celia became a small volcano, since she was composed of the same sorts of substances which commonly clogged drains. '

--- 1973. KURT VONNEGUT. "Breakfast of Champions, or, Goodbye Blue Monday." Chapter 6 (Page 65).
by Dinkum February 15, 2014
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Mike was known for making unlimited shots at the 3 point line so we called him Drano.
by Blaqjade13 December 24, 2019
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A semi-derisive slang term for the Draenei, a playable character race on the Alliance side from Blizzard's MMORPG World of Warcraft.
We wiped again! Who let that Drano idiot tank?
by CoilSlade February 6, 2010
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The first coffee of the morning, which compels you to go and empty your bowels.
Liam was horrendously constipated, and late for work. He needed a good cup of colombian drano.
by Deathglooms April 2, 2014
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Something to make when bored. You will get addicted after you make the first one, and try to find ways to make it bigger and better.
A: Hey, what are you doing now?
B: Nothing.
A: Do you want to go make a drano bomb near sunny slopes.
B: Isn't that close to the police station.
A: Who cares?
B: Sure!
by Stizzz May 2, 2007
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Put commercal toilet cleaner with aluminum in a bottle. will blow up im 3 secs after cap is closed. ***warning will blind you!!!***
by Anonymous August 17, 2003
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Any Mexican meal that once ingested rockets through your stomach and out "unclogging the drain".
Lisa and I had dinner at Loco Mexico last night and the Mexican Drano hit the porcelain an hour later.
by Urban humor August 9, 2017
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