Top Definition
to reverse the fucked-up-ness of a fucked up sleep schedule.
"Maybe you should try to maintain something remotely resembling a sleep schedule."

"I have one -- it's just fucked up."

"Then maybe you should defuckify."
1 more definition
The eventual act of regaining one's sanity after a prolonged duration of a (poorly thought out) substance-induced altered state of consciousness.
"I called in sick to my parents. I can't see them right now. I need to defuckify".
...Let's have some wine. It will help. I swear. (10:30 am)
by tunak December 10, 2008

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