Top definition
the prank in which one person tricks another by suggesting that if one's hand is bigger than their face, they have cancer. But upon placing their hand over their face, to test themselves out, the prankster smacks the person's hand into their own face.

*Origin: Unknown...does anyone know when this was created?
"Did you the Family Guy clip when Tom Tucker pulls that 'cancer of the face' prank on Diane Simmons during the Quahog News?"
by Little Big Daddy December 17, 2011
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