New name for, yes, yet another tiny section of New York City's lower Manhattan - South Bowery - SoBo refers to the small section of land between Chrystie and Bowery, below 2nd street and above Grand. This area is particuarlly diverse, adding quite a bohemian (boho) charm, including a cross section of 'hoods Chinatown, Soho, Nolita, Lower East Side, Little Italy and the East Village.

In this small area one can find samples of each bordering neighborhood such as; new galleries opening along 2nd street which are across from the Anthology Film Archives north of Avalon Condos and a Whole Foods which is sitting right next to the LES Low-income Housing Projects that are next to the Bowery Mission, right next to the new New Musuem, bordering a wild night club, next to a fancy Chinatown restaurant accross from the exclusive "Freeman's Ally including an upscale men's barbar and french restaurant, next to a great lumbar/hardware warehouse accross from a cheap European style hotel and cady corner from a beloved indie filmmaker (to remain nameless), who is just above some of the greatest Chinatown grocery shopping, where one can watch local Italians, Spainards, Mexicans, Chinese and many others play "American Soccer" at the Rosevelt Park and then go for food at the Romanian Family style restaurant Sammy's. We call this SoBo. And it is So Bohemian.
I live on Rivington Street, between Chrystie and Bowery, right in the heart of SoBo.
by neighborhood resident February 02, 2007
short for South Boston aka southie MA, a hood in boston. No one in boston and southie calls it sobo. This is a term coined by realtors to make southie sound trendy like the back by or south end. This term is harshly rejected by long time southie residents who know its a gimmick to lure in rich yuppie bastards.
Yuppie- "I'm moving to Sobo where I will buy a condo for $500,000so I will be closer to my cube downtown"

Southie Guy- "Are ya Fackin retaded its called southie, not sobo you yuppie bastard,move back to vermont"
by $teve December 27, 2006
South Bound. Used in describing direction on hiking trails such as the long trail and the appalachian trail.
I'm gonna do the long trail sobo.
by ISE91 June 29, 2008
Socks On, Balls Out
Bro, I was hardcore SOBOing last weekend after all that Jager. You check that?
by MikeFrisco May 28, 2013
slang term for the drug suboxone
Jean: "Hey Wally I'm all out of heroin, can I buy a sobo?"
Wally: "One for $10 or five for $40?"
Jean: "Can I just give you a quick Handy for one? Or I'll give you a Blumpkin for the five"
Wally: "I can't part with my sobos that easy Jean. Let me give you an angry dragon and you can have half my script"
Jean: "Ok"
by sanf April 24, 2011
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