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1.
South Bombay
SoBo is so much better than NoBo
by BombayHustle October 15, 2009
 
2.
South Bound. Used in describing direction on hiking trails such as the long trail and the appalachian trail.
I'm gonna do the long trail sobo.
by ISE91 June 29, 2008
 
3.
short for South Boston aka southie MA, a hood in boston. No one in boston and southie calls it sobo. This is a term coined by realtors to make southie sound trendy like the back by or south end. This term is harshly rejected by long time southie residents who know its a gimmick to lure in rich yuppie bastards.
Yuppie- "I'm moving to Sobo where I will buy a condo for $500,000so I will be closer to my cube downtown"

Southie Guy- "Are ya Fackin retaded its called southie, not sobo you yuppie bastard,move back to vermont"
by $teve December 27, 2006
 
4.
Socks On, Balls Out
Bro, I was hardcore SOBOing last weekend after all that Jager. You check that?
by MikeFrisco May 28, 2013
 
5.
A sexual deviant, a person who sleeps with a variety of people.
That's what Sobo said.
by MonkeyBallz December 26, 2007
 
6.
A very laidback person.
You are such a sobo.
by sobo August 08, 2005
 
7.
slang term for the drug suboxone
Jean: "Hey Wally I'm all out of heroin, can I buy a sobo?"
Wally: "One for $10 or five for $40?"
Jean: "Can I just give you a quick Handy for one? Or I'll give you a Blumpkin for the five"
Wally: "I can't part with my sobos that easy Jean. Let me give you an angry dragon and you can have half my script"
Jean: "Ok"
by sanf April 24, 2011