To engage in intercourse with the family dog.
Boy, Sparky's looking tired today. Mom must have really screwed the pooch last night.

OR

Timmies' got blue balls, so I told him to screw the pooch.
by MonickerBazillion December 3, 2010
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To have sex with a dog.
Jize Layo screwed the pooch for his new film, "Jize Layo does a dachsund IV"
by Jose Loya August 15, 2005
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In skateboarding, to lose control of the board and crush one's testicles on a rail, bar, lip, or other similar surface.
Tony tried to grind down the handrail at school, but instead he just managed to screw the pooch.
by Fresnel February 25, 2009
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When management of a venture-backed company miss their numbers.
Molly Ashby always loved the opportunity to tell her fellow board members that management screwed the pooch last quarter; Brian Watson creamed his pants when she said that.
by madmark65 July 24, 2004
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Screwing the pooch is a nonsensical action that is being done while a major fuck up is occuring or has occured.
Management have screwed the pooch while the competition gained the upperhand.
by ANTZILLA July 13, 2014
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Meaning to err greatly. Literally meaning to accidently achieve an orgasm when fooling around to get your sausage up in a girls guts. Hence, a catostrophic fuck up.
ex 1: We really can't screw the pooch in the 4th quarter, boys.

ex2: guy1-" I was so nervous with sheniqua last night that i screwed the pooch."
guy2- " ouch dude, ouch.
guy1-" ehhhh, it was good for me."
by Ollie Vector November 20, 2006
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